Nirmatrelvir/Ritonavir

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4 Relevant Research Studies

Most-Reviewed Use: ANTIBIOTICS

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Brand Name: Paxlovid

Drug Class: Antiviral - protease inhibitor

FDA Category: Prescription Medication

CompendiRx Topic(s): Antivirals and Antibiotics

Dosage Form: Tablet Tablet - 150mg/100mg

Common Usage: COVID diagnosis

How it works

Inhibits protease enzyme during viral replication

Pregnancy

In general, the treatment of COVID-19 infection during pregnancy is the same as in nonpregnant patients. However, because data for most therapeutic agents in pregnant patients are limited, treatment options should be evaluated as part of a shared decision-making process. Pregnancy is a risk factor for severe COVID-19; the use of nirmatrelvir and ritonavir is recommended if indicated

Lactation

Breast milk has not been found to be a source of COVID-19 infection and maternal infection is not a contraindication to breastfeeding. Breastfeeding can continue if nirmatrelvir and ritonavir are needed for the management of COVID-19

Warnings

Black Box Warning: CYP3A4 inhibitors Contraindicated: Hypersensitivity to Paxlovid ; Warnings: Hepatotoxicity, risk of HIV-1 resistance development, renal impairment

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